Evaluating Serum RBP4 as an Auxiliary Biomarker for CKDu Diagnosis

Background: A chronic interstitial disease, kidney disease of uncertain etiology (CKDu), has emerged as a notable contributor to the CKD burden in rural Sri Lanka. Most therapeutic and diagnostic approaches focus on glomerular diseases, thus are not fully applicable CKDu. Serum proteins, specifically those with profile markers representing different facets beneficial for comprehensive evaluation hence CKD. Our aim was identify role serum-retinol-binding protein 4 (RBP4), marker proximal tubule, diagnosis Methods: Definite CKDu cases were recruited from renal clinic Girandurukotte Wilgamuwa (endemic regions). Healthy controls Mandaramnuwara (nonendemic area). The levels RBP4 creatinine serum measured. An immunoassay (ELISA) performed samples. stages CKD/ classified according eGFR. Results: significantly increased patients compared healthy controls. results show that ratio normalized creatine (S.cr) acts better competitive (AUC 0.762, sensitivity 0.733) than 0.584, when against Furthermore, RBP4:S.cr showed higher discriminating power 0.743) between CKD, suggesting RBP4: S.cr potential differentiate Conclusion: identified plausible indicator differentiating >70% specificity. Therefore, it could be used tubular involvement